01 Aug Male Fertility and Sperm DNA Fragmentation: How Lifestyle Can Impact Your Chances of Success
When couples face fertility challenges, the focus often falls on the woman. But studies show that male factors are involved in approximately 40 to 50 percent of infertility cases. Despite this, many men are never properly evaluated, and potential issues like sperm DNA fragmentation go undiagnosed.
At Pelargos IVF, we believe fertility is a shared journey. Our personalized treatment approach ensures that both partners are evaluated thoroughly. In this article, we explore sperm DNA fragmentation and how daily habits can influence male fertility and IVF outcomes.
What Is Sperm DNA Fragmentation?
Sperm DNA fragmentation refers to damage in the genetic material carried by sperm. Unlike basic semen analysis, which looks at count, motility, and morphology, a DNA fragmentation test reveals the stability of the sperm’s genetic content.
High levels of DNA fragmentation have been linked to lower fertilization rates, poor embryo development, failed implantation, and even early miscarriage. This applies to both natural conception and assisted reproduction techniques like IVF and ICSI.
How Is Sperm DNA Fragmentation Measured?
Sperm DNA fragmentation can be assessed through several lab tests such as the SCSA (Sperm Chromatin Structure Assay), TUNEL assay, and the Comet assay. These tests measure the percentage of sperm with fragmented DNA. A score below 15 percent is typically considered low, while levels above 30 percent are associated with a significant reduction in fertility potential.
At Pelargos IVF, we often recommend DNA fragmentation testing in cases of unexplained infertility, recurrent IVF failure, or miscarriage, especially when standard semen analysis appears normal.
Common Causes of DNA Damage in Sperm
DNA fragmentation can result from several factors, both medical and lifestyle-related:
- – Oxidative stress caused by an imbalance between antioxidants and free radicals
- – Smoking and exposure to secondhand smoke
- – High alcohol intake and recreational drug use
- – Chronic stress, poor sleep, and obesity
- – Advanced age, particularly over 40
- – Environmental toxins such as pesticides, heavy metals, and plastics
- – Frequent heat exposure like hot baths, saunas, or laptops placed on the lap
- – Medical conditions such as varicocele, infections, and hormonal imbalances
Many of these causes are reversible, and with appropriate intervention, sperm quality can improve within three to six months.
How Lifestyle Changes Can Improve Sperm DNA Quality
Making a few targeted changes can make a significant difference in sperm health. These include:
- – Eating a diet rich in antioxidants (vitamin C, E, zinc, selenium, omega-3)
- – Reducing alcohol intake and quitting smoking
- – Managing stress through mindfulness, therapy, or exercise
- – Sleeping at least 7 to 8 hours per night
- – Maintaining a healthy weight and regular physical activity
- – Avoiding hot tubs, tight underwear, and prolonged laptop use on the lap
- – Limiting exposure to chemicals found in plastics, pesticides, and cleaning agents
It’s important to understand that sperm regenerate approximately every 72 days. This means lifestyle changes can lead to measurable improvements within 2 to 3 months.
Can Sperm DNA Fragmentation Be Treated?
Yes. If DNA fragmentation is high, a fertility specialist may recommend several approaches:
- – Antioxidant supplements tailored to the individual’s lab profile
- – Treatment of underlying conditions such as varicocele
- – Frequent ejaculation to reduce sperm storage time
- – Advanced sperm selection techniques in IVF such as IMSI or MACS
- T- esticular sperm extraction (TESE) in severe cases, where testicular sperm often show lower DNA damage than ejaculated sperm
At Pelargos IVF, we work with leading andrology labs and urologists to support men with high fragmentation scores. Our fertility team integrates these findings into customized IVF protocols to improve success rates.
When Should Men Get Tested?
Any man trying to conceive should consider a fertility evaluation if:
- – Pregnancy has not occurred after 12 months of unprotected intercourse (or 6 months if the woman is over 35)
- – There is a history of miscarriage or failed IVF attempts
- – The man has known risk factors such as smoking, varicocele, infections, or occupational exposures
- – Basic semen analysis is normal, but pregnancy is still not happening
What We Offer at Pelargos IVF
Our clinic goes beyond standard IVF protocols. We emphasize holistic care, combining the latest science with a personalized approach. We offer:
- – Comprehensive male fertility testing, including sperm DNA fragmentation
- – Collaboration with urologists and reproductive immunologists when needed
- – Lifestyle and nutrition guidance
- – Tailored IVF protocols for couples with male factor infertility
- – Emotional and psychological support for both partners
You can learn more about our approach and team at Pelargos IVF’s official site.
Final Thoughts: It’s Not Just a Female Issue
Fertility is a couple’s responsibility, and identifying hidden issues like sperm DNA fragmentation can change everything. Men can take meaningful steps toward improving their fertility, often with minimal intervention and major impact.
Ignoring male factors can delay diagnosis, add emotional stress, and result in costly or unsuccessful IVF attempts. But early awareness and action can significantly boost your chances of building the family you dream of.
Take the Next Step
If you’ve been trying to conceive without success or have experienced multiple failed IVF attempts, it may be time to look deeper. Reach out to Pelargos IVF for a personalized consultation. Our experienced team will guide you with empathy and medical excellence, every step of the way.
Visit www.pelargosivf.com to book your appointment or explore our services.
Sources
Agarwal A et al. (2016). Sperm DNA fragmentation: causes, evaluation, and treatment. Andrologia.
Esteves SC et al. (2021). Sperm DNA fragmentation testing: A consensus guideline from the WHO.
ASRM Practice Committee. (2020). The role of sperm DNA integrity testing in the evaluation of male infertility. Fertility and Sterility.
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